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Nico M Wulffraat Selected Research

Juvenile Arthritis (Juvenile Idiopathic Arthritis)

4/2022Real-world data reveals the complexity of disease modifying anti-rheumatic drug treatment patterns in juvenile idiopathic arthritis: an observational study.
1/2022Increased incidence of inflammatory bowel disease on etanercept in juvenile idiopathic arthritis regardless of concomitant methotrexate use.
1/2022Perspectives of Pediatric Rheumatologists on Initiating and Tapering Biologics in Patients with Juvenile Idiopathic Arthritis: A Formative Qualitative Study.
12/2021Association of adalimumab trough concentrations and treatment response in patients with juvenile idiopathic arthritis.
12/2020Efficacy and Safety of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis With and Without Fever at Baseline: Results From an Open-Label, Active-Treatment Extension Study.
2/2020Pharmacological conditioning for juvenile idiopathic arthritis: a potential solution to reduce methotrexate intolerance.
1/2020The Patient and Parent Perspective on Methotrexate in Recent Juvenile Idiopathic Arthritis Guidelines: Comment on the Article by Ringold et al.
10/2019Bone-marrow derived mesenchymal stromal cells infusion in therapy refractory juvenile idiopathic arthritis patients.
1/2019Treatment to Target Using Recombinant Interleukin-1 Receptor Antagonist as First-Line Monotherapy in New-Onset Systemic Juvenile Idiopathic Arthritis: Results From a Five-Year Follow-Up Study.
12/2018Canakinumab in patients with systemic juvenile idiopathic arthritis and active systemic features: results from the 5-year long-term extension of the phase III pivotal trials.
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Nico M Wulffraat Research Topics

Disease

50Juvenile Arthritis (Juvenile Idiopathic Arthritis)
04/2022 - 02/2003
13Arthritis (Polyarthritis)
01/2016 - 02/2011
7Infections
01/2021 - 02/2004
7Rheumatic Diseases (Rheumatism)
01/2019 - 06/2012
6Uveitis
01/2018 - 04/2013
6Autoimmune Diseases (Autoimmune Disease)
12/2017 - 11/2006
4Rheumatoid Arthritis
01/2019 - 01/2013
4Necrosis
01/2018 - 02/2011
3Systemic Lupus Erythematosus (Libman-Sacks Disease)
01/2019 - 09/2013
3Dermatomyositis (Dermatopolymyositis)
01/2016 - 05/2013
3Inflammation (Inflammations)
01/2015 - 05/2007
3Pain (Aches)
01/2015 - 04/2013
2Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
01/2022 - 07/2011
2Poliomyelitis (Polio)
01/2020 - 03/2018
2Macrophage Activation Syndrome
10/2019 - 03/2010
2Myositis (Idiopathic Inflammatory Myopathies)
01/2019 - 05/2013
2Psoriatic Arthritis
09/2014 - 01/2013
2Measles
06/2013 - 06/2012
2Rubella (German Measles)
06/2013 - 06/2012
2Mumps
06/2013 - 06/2012
2Neoplasms (Cancer)
01/2013 - 11/2006
2Tetanus
06/2012 - 02/2007
1COVID-19
01/2021
1Fever (Fevers)
12/2020
1Hepatitis B
01/2019
1Spondylitis
01/2019
1Diarrhea
03/2018
1Fatigue
02/2018
1Crohn Disease (Crohn's Disease)
12/2017
1Systemic Scleroderma (Systemic Sclerosis)
12/2017
1Proteinuria
12/2017
1Reticular dysgenesis
01/2017
1Acquired Immunodeficiency Syndrome (AIDS)
01/2016
1Mucopolysaccharidosis I (Hurler Syndrome)
03/2015
1Negative rheumatoid factor polyarthritis
02/2015
1Experimental Arthritis
02/2014
1Tuberculosis (Tuberculoses)
01/2013
1Diphtheria
06/2012
1Hypersensitivity (Allergy)
03/2012

Drug/Important Bio-Agent (IBA)

16Methotrexate (Mexate)FDA LinkGeneric
01/2022 - 07/2011
9Biological ProductsIBA
07/2015 - 02/2011
8Etanercept (Enbrel)FDA Link
01/2022 - 03/2010
8VaccinesIBA
01/2021 - 11/2011
7Antirheumatic Agents (DMARD)IBA
04/2022 - 01/2014
6Pharmaceutical PreparationsIBA
04/2017 - 09/2012
4Adalimumab (Humira)FDA Link
12/2021 - 10/2011
4canakinumabFDA Link
12/2020 - 04/2013
3Antinuclear AntibodiesIBA
01/2019 - 01/2015
3Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link
04/2014 - 11/2004
2Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
01/2019 - 04/2014
2Rheumatoid FactorIBA
01/2019 - 09/2014
2InterleukinsIBA
03/2018 - 04/2013
2Interleukin-6 (Interleukin 6)IBA
03/2018 - 12/2013
2Proteoglycans (Proteoglycan)IBA
01/2016 - 02/2014
2Biomarkers (Surrogate Marker)IBA
02/2015 - 06/2014
2CytokinesIBA
09/2014 - 05/2007
2Papillomavirus Vaccines (HPV Vaccines)IBA
08/2014 - 09/2013
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2013 - 10/2011
2Tumor Necrosis Factor InhibitorsIBA
09/2013 - 02/2011
2AntibodiesIBA
01/2013 - 06/2012
2Immunoglobulin G (IgG)IBA
06/2012 - 02/2007
2EnzymesIBA
04/2011 - 02/2007
2Sulfasalazine (Azulfidine)FDA LinkGeneric
11/2007 - 02/2003
1amsonic acid (DAS)IBA
12/2021
1GlucocorticoidsIBA
12/2020
1SolutionsIBA
02/2020
1tocilizumab (atlizumab)FDA Link
10/2019
1insulin receptor-related receptor (IRR)IBA
01/2019
1Hepatitis B Surface Antigens (HBsAg)FDA Link
01/2019
1Attenuated VaccinesIBA
03/2018
1Serine (L-Serine)FDA Link
01/2018
1Amino AcidsFDA Link
01/2018
1Prednisone (Sone)FDA LinkGeneric
12/2017
1Antiphospholipid AntibodiesIBA
10/2017
1T-Cell Antigen Receptors (T-Cell Receptor)IBA
01/2016
1HLA Antigens (Human Leukocyte Antigens)IBA
02/2015
1methotrexate polyglutamateIBA
02/2015
1C-Reactive ProteinIBA
02/2015
1CreatinineIBA
01/2015
1Interleukin-1 (Interleukin 1)IBA
01/2015
1Alanine Transaminase (SGPT)IBA
01/2015
1Proteins (Proteins, Gene)FDA Link
06/2014
1S100A12 ProteinIBA
06/2014
1SteroidsIBA
04/2014
1NAD (NADH)IBA
12/2013
1Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA
12/2013
1Creatine Kinase (Creatine Phosphokinase)IBA
05/2013
12-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA
05/2013
1Monoclonal AntibodiesIBA
04/2013
1Tetanus Toxoid (Vaccine, Tetanus)FDA Link
06/2012

Therapy/Procedure

10Therapeutics
02/2020 - 11/2006
5Stem Cell Transplantation
04/2017 - 06/2004
3Biological Therapy
01/2022 - 12/2011
3Transplantation
12/2017 - 09/2010
3Hematopoietic Stem Cell Transplantation
12/2017 - 09/2010
2Bone Marrow Transplantation (Transplantation, Bone Marrow)
01/2016 - 11/2006
1Drug Tapering
12/2020
1Pain Management
02/2018
1Patient Transfer (Patient Dumping)
01/2018
1Cell Transplantation
03/2015